![]() Results and formation process, including the influence of laser parameters, are discussed. The process is carried out in the open air and in an argon atmosphere using two different laser sources. In the present work, we report the synthesis and deposition of copper and copper oxide nanoparticles on cp Ti substrates in a one-step process by laser ablation. More recently, copper nanoparticles with different degrees of oxidation were also obtained by laser ablation in water and methanol, in order to demonstrate their cytocompatibility and bacteriological activity against Aggregatibacter actinomycetemcomitans. In previous works, silver nanoparticles were obtained by laser ablation in open air, and their antibacterial properties against Lactobacillus salivarius were then probed. In other techniques, the use of surfactants or the use of chemical precursors produces the contamination of the nanoparticles with agents potentially toxic for human cells. On the other hand, the absence of potentially toxic chemicals makes this technique a preferred choice for the preparation of nanoparticles. The technique of laser ablation in gaseous media used in the present study allows researchers to obtain nanoparticles with reduced average sizes. But not only is the size behind these particular properties, but also shape of the particles, which depends upon the fabrication method. In particular, the antibacterial activity of copper and its oxides when the size is reduced to nanoscale is of great interest because of a high surface to volume ratio, which allows doctors to kill the pathogens without affecting the healthy tissue that surrounds it. In addition, copper is part of a good number of enzymes, and is involved in tissue respiration. It works as an agent to help integrate iron, zinc and vitamin C, besides being essential for the brain and its neurotransmissions, energy production, and to regulate several hormonal processes. That is, an element necessary for the proper functioning of the human body in amounts less than 100 mg per day, there being recommended a daily copper intake of around 1.4 mg for an adult weighing about 70 kg. Among these elements, noble metal and transition metal nanoparticles are attracting great interest due to their remarkable antibacterial properties.Ĭopper, besides the fact that it is potentially effective against different bacterial pathogens, is a trace element. To promote an antimicrobial response from implants, some metallic antibacterial elements have been incorporated into implants’ surfaces and matrices. aureus in some oral infections such as peri-implantitis, which is considered the main cause of dental implant failure. Furthermore, several researchers have demonstrated the important role of this S. Staphylococcus aureus, in addition to being related to a large number of infectious diseases, is one of the bacteria that presents a greater resistance to current commercial antibiotics. Currently, antibiotic resistance kills an estimated 700,000 people each year, and some experts predict that the number could rise to 10 million by 2050, if efforts to curtail resistance or develop new antibiotics are not made. According to the World Health Organization (WHO), “the post-antibiotic era”, where no treatment for infections and minor injuries exists, is near. The decreasing effectiveness of antibiotics and other antimicrobial agents is a global concern. The synthesized and deposited nanoparticles exhibited an inhibitory effect upon S. The use of the argon atmosphere contributed to reduce significantly the formation of Cu oxide species. The obtained deposits consisted of porous coatings composed of copper and copper oxide nanoparticles interconnected to form chain-like aggregates. The UV-VIS absorbance of the thin layer of nanoparticles was also measured, and the antibacterial capacity of the obtained deposits tested against Staphylococcus aureus. Size, morphology, composition and the crystalline structure of the produced nanoparticles have been studied by the means of field emission scanning electron microscopy (FESEM), high resolution transmission electron microscopy (HRTEM), the energy dispersive spectroscopy of X-rays (EDS), selected area electron diffraction (SAED) and X-ray diffraction (XRD). In this work, Cu and Cu oxide nanoparticles were synthesized by laser ablation in open air and in argon atmosphere using 5 nm radiation generated by nanosecond and picosecond Nd:YVO 4 lasers, respectively, to be directly deposited onto Ti substrates. Copper nanoparticles and their huge potential as a bactericidal agent could be a solution. The proximity of the “post-antibiotic era”, where infections and minor injuries could be a cause of death, there are urges to seek an alternative for the cure of infectious diseases. ![]()
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